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Filtered Search Results
Medchemexpress LLC Tivozanib hydrochloride hydrate | 682745-41-1 | 99.8% | 509.34 | 10 MM 1 ML
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Tivozanib hydrochloride hydrate is the hydrate hydrochloride form of Tivozanib. It is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2, and 3. This compound exhibits antitumor efficacy.
- Selective, orally active inhibitor for VEGFR-1, 2, and 3
- Exhibits antitumor efficacy
- Available in solid form, white to off-white color
- Soluble in DMSO (125 mg/mL)
- Inhibits the phosphorylation of VEGFR-1, VEGFR-2, and VEGFR-3
- Inhibits VEGF-induced proliferation and migration of HUVECs
- Selectively inhibits VEGF-stimulated phosphorylation of MAPKs in endothelial cells
- Exhibits antitumor efficacy against various cancers in athymic mice models
- Reversibly suppresses vascular permeability and angiogenesis in tumor-bearing rats
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Biotang Inc Rociletinib, Free Base, > 99%, 10MG, AVL-301;CNX-419;CO-1686. M.W. 555.55. C27H28F3N7O3. CAS#1374640-70-6
Rociletinib, Free Base, > 99%, 10MG, AVL-301;CNX-419;CO-1686. M.W. 555.55. C27H28F3N7O3. CAS#1374640-70-6
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Medchemexpress LLC HY-70074 5mg Medchemexpress, CCG-63802 CAS:620112-78-9 Purity:>98%
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Medchemexpress, HY-70074 5mg CCG-63802 CAS:620112-78-9 CCG-63802 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-Gαo interaction, with an IC50 value of 1.9 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Hxr9 hydrochloride | 99.5% | 2754.67 | 10 MG
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HXR9 hydrochloride is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. It works by antagonizing the interaction between HOX and PBX, a transcription factor that binds to HOX proteins in paralogue groups 1 to 8. This compound selectively decreases cell proliferation and promotes apoptosis in cells that highly express HOXA/PBX3 genes, such as MLL-rearranged leukemic cells.
- Cell-permeable peptide
- Competitive antagonist of HOX/PBX interaction
- Decreases cell proliferation
- Promotes apoptosis
- Blocks tumor growth in vivo
- Causes specific transcriptional changes
- Potential therapeutic target
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eMolecules 933755-97-6 | 1-Ethynylcyclopropanecarboxylic acid | MFCD19231569 | 100mg
Ambeed | 1-Ethynylcyclopropanecarboxylic acid | 100mg | 490558615 | A379110 | 933755-97-6 | MFCD19231569 | 110.112 | C6H6O2
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Medchemexpress LLC S-verapamil hydrochloride | 36622-28-3 | MFCD11045898 | 98.3% | C27H39ClN2O4 | 10MG
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(S)-Verapamil hydrochloride is the S-enantiomer of the calcium channel blocker verapamil, supplied as the hydrochloride salt for use in pharmacology and transporter research. It is reported to inhibit leukotriene C4 (LTC4) and calcein transport by the multidrug resistance protein MRP1 and is provided as a high-purity research reagent.
- Enantiomer-specific activity useful for stereoselective studies.
- Suitable for transporter and pharmacology assays.
- Hydrochloride salt form improves solubility in polar solvents.
- Reported inhibition of LTC4 and MRP1-mediated transport.
- High purity (98.3%) for reproducible experimental results.
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Medchemexpress LLC HY-19830 5mg Medchemexpress, AN3199 CAS:1187187-10-5 Purity:>98%
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Medchemexpress, HY-19830 5mg AN3199 CAS:1187187-10-5 AN3199 is a PDE4 inhibitor with an IC50 of 94.5 nM. AN3199 can be used for the research of inflammation-associated diseases such as asthma and chronic obstructive pulmonary disease (COPD). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC MCOPPB trihydrochloride | 1108147-88-1 | 99.98% | 100 MG
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MCOPPB trihydrochloride is a nociceptin receptor agonist with a pKi of 10.07, demonstrating weaker activity at other opioid receptors. It is the trihydrochloride form of MCOPPB, which is described as a new nonpeptide nociceptin/orphanin FQ peptide (NOP)-receptor agonist. It has a pKi of 10.07 ± 0.01 for the human NOP receptor. This product is for research use only.
- Nociceptin receptor agonist
- Weaker activity at other opioid receptors
- Nonpeptide nociceptin/orphanin FQ peptide (NOP)-receptor agonist
- For research use only
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Medchemexpress LLC HY-B0161A 50mg Medchemexpress, Duloxetine (hydrochloride) CAS:136434-34-9 Purity:>98%
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Medchemexpress, HY-B0161A 50mg Duloxetine (hydrochloride) CAS:136434-34-9 Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-101976 10mg Medchemexpress, JAK3-IN-6 CAS:1443235-95-7 Purity:>98%
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Medchemexpress, HY-101976 10mg JAK3-IN-6 CAS:1443235-95-7 JAK3-IN-6 is a potent, selective irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-109142 10mg Medchemexpress, Ziresovir CAS:1422500-60-4 Purity:>98%
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Medchemexpress, HY-109142 10mg Ziresovir CAS:1422500-60-4 Ziresovir (AK0529;RO-0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion (F) protein (RSV F) protein inhibitor. Ziresovir shows anti-RSV activity (EC50=3 nM) and highlights pharmacokinetics in animal species. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-10929 5mg Medchemexpress, UNC0224 CAS:1197196-48-7 Purity:>98%
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Medchemexpress, HY-10929 5mg UNC0224 CAS:1197196-48-7 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-109142 5mg Medchemexpress, Ziresovir CAS:1422500-60-4 Purity:>98%
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Medchemexpress, HY-109142 5mg Ziresovir CAS:1422500-60-4 Ziresovir (AK0529;RO-0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion (F) protein (RSV F) protein inhibitor. Ziresovir shows anti-RSV activity (EC50=3 nM) and highlights pharmacokinetics in animal species. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC BRD4 inhibitor-24 | 309951-18-6 | 99.3% | C13H14N2O4 | 10MG
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BRD4 Inhibitor-24 is a high-purity small-molecule inhibitor of the BRD4 bromodomain with reported antitumor activity in MCF7 and K562 cells. Supplied for research use, it is characterized for molecular properties, solubility, and storage to support in vitro and in vivo studies.
- High purity (99.3%).
- Molecular formula C13H14N2O4; molecular weight 262.26.
- Reported antitumor activity in MCF7 and K562 cell lines.
- High solubility in DMSO (≥100 mg/mL) and suitable in vivo formulation (≥2.5 mg/mL in 10% DMSO, 90% corn oil).
- Defined storage stability in solution: -80°C for up to 6 months, -20°C for up to 1 month.
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Medchemexpress LLC HY-103083 5mg Medchemexpress, GPR40 agonist 4 CAS:2102196-57-4 Purity:>98%
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Medchemexpress, HY-103083 5mg GPR40 agonist 4 CAS:2102196-57-4 GPR40 agonist 4 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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